A Phase ? Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

Active:	Yes
Cancer Type:	Stomach/ Gastric Cancer Unknown Primary	NCT ID:	NCT06764875
Trial Phases:	Phase III	Protocol IDs:	D702AC00001 (primary) NCI-2025-03123 2024-512583-57-00
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	AstraZeneca Pharmaceuticals LP
NCI Full Details:	http://clinicaltrials.gov/show/NCT06764875

Summary

This is a Phase ?, randomized, open-label, Sponsor-blinded, 3-arm, global, multicenter
study assessing the efficacy and safety of rilvegostomig in combination with
fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and
pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ
adenocarcinoma participants whose tumors express PD L1 CPS = 1. Rilvegostomig in
combination with trastuzumab and chemotherapy will be evaluated in a separate arm (Arm C)
to assess the contribution of each component in the experimental arm.

Objectives

The purpose of this study is to assess the efficacy and safety of rilvegostomig in
combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab,
chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic
gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS = 1.
Rilvegostomig in combination with trastuzumab and chemotherapy will be evaluated in a
separate arm (Arm C) to assess the contribution of each component in the experimental
arm.

This study will be conducted at up to 200-250 sites globally in approximately 25
countries.

Treatment Sites in Georgia

Northwest Georgia Oncology Centers - Cobb Hospital (Hiram)
144 Bill Carruth Parkway
Suite 3100
Hiram, GA 30141
770-281-5131
www.ngoc.com

Northwest Georgia Oncology Centers - Douglasville
6002 Professional Parkway
Suite 140
Douglasville, GA 30134
770-281-5101
www.ngoc.com

Northwest Georgia Oncology Centers - Tanner Medical Center Villa Rica
157 Clinic Avenue
Suite 202
Carrollton, GA 30117
770-281-5101
www.ngoc.com

Northwest Georgia Oncology Centers (NGOC) - Cobb Hospital (Marietta)
340 Kennestone Hospital Blvd.
Suite 100
Marietta, GA 30060
770-281-5101

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