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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC = 50%) and Without Actionable Genomic Alterations


Active: Yes
Cancer Type: Lung Cancer
Unknown Primary
NCT ID: NCT06357533
Trial Phases: Phase III Protocol IDs: D7632C00001 (primary)
NCI-2024-07729
2023-505077-32-00
Eligibility: 18 Years and older, Male and Female Study Type: Treatment
Study Sponsor: AstraZeneca Pharmaceuticals LP
NCI Full Details: http://clinicaltrials.gov/show/NCT06357533

Summary

The purpose of this study is to evaluate efficacy and safety of Dato-DXd in combination
with rilvegostomig or rilvegostomig monotherapy compared with pembrolizumab monotherapy
as a first line therapy in participants with locally advanced or metastatic non-squamous
NSCLC with high PD-L1 expression (TC = 50%) and without actionable genomic alterations.

Objectives

This is a Phase III, randomized, open-label, Global Study of Datopotamab Deruxtecan
(Dato-DXd) in Combination With Rilvegostomig or Rilvegostomig monotherapy versus
Pembrolizumab monotherapy for the first-line treatment of participants with
locally-advanced or metastatic non-squamous NSCLC with high PD-L1 expression (TC = 50%)
and without actionable genomic alterations.

Treatment Sites in Georgia

Piedmont Cancer Institute - Atlanta
1800 Howell Mill Road
Suite 800
Atlanta, GA 30318
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute - Fayetteville
1267 Highway 54 West
Suite 4200
Fayetteville, GA 30214
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute – Locust Grove
4877 Bill Gardner Pkwy
Locust Grove, GA 30248




Piedmont Cancer Institute - Newnan
775 Poplar Road
Suite 310
Newnan, GA 30265
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute – Sandy Springs
Piedmont Cancer Institute – Sandy Springs
755 Mount Vernon Hwy
Suite 320
Atlanta, GA 30328




Piedmont Cancer Institute - Stockbridge
290 Country Club Drive
Suite 100
Stockbridge, GA 30281
678-298-3238
www.piedmontcancerinstitute.com



Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.